Dragon Drool is a substance Vanity and his fellow Smurfs have found in Papa Smurf's locked chest in the 2021 cartoon show episode "Joke's On You". It appears as small glowing blue balls and emit a powder that does magical things.
In the episode, Vanity uses powdered Dragon Drool as part of his surprise package for Jokey. When he opened it, the blue powder exploded, creating a miniature version of Jokey who also held a surprise package which, when exploded, created yet another "mini-Jokey". Eventually, Papa Smurf found out who used the Dragon Drool and scolded both Vanity and Jokey, telling them to get the little jokesters under control.